Hi! My name is Nishanth Merwin and I'm currently a researcher working under Dr. Nathan Magarvey in the Institute for Infectious Disease Research. Currently, my research aims to accelerate the discovery and characterization of natural products (chemicals produced by living organisms). Through developing new genome analytical toolkits (such as PRISM), and metabolomic analysis pipelines, we're now able to identify and isolate novel small molecules at an unprecendented rate.
I also work closely with Adapsyn Bioscience as their genomics and data science consultant. Here, our goal is to use our top notch technology to translate these discoveries into the clinic for therapeutic use.
NGS Data management and analysis (PacBio, Illumina)
Wrangling around with software until I find a solution
Skinnider MA, Johnston CW, Merwin NJ, Dejong CA, Magarvey NA. Global analysis of prokaryotic tRNA-derived cyclodipeptide biosynthesis. BMC Bioinformatics 2018; doi:10.1186/s12864-018-4435-1
Mousa WK, Athar B, Merwin NJ, Magarvey NA. Antibiotics and specialized metabolites from the human microbiota. Natural Product Reports 2017; doi:10.1039/c7np00021a
Skinnider MA, Merwin NJ, Johnston CW, Magarvey NA. PRISM 3: expanded prediction of natural product chemical structures from microbial genomes. Nucleic Acids Research 2017; doi:10.1093/nar/gkx320
Skinnider MA, Johnston CW, Edgar RE, Dejong CA, Merwin NJ, Rees PN, et al. Genomic charting of ribosomally synthesized natural product chemical space facilitates targeted mining. Proceedings of the National Academy of Sciences 2016; doi:10.1073/pnas.1609014113